| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Potassium channel subfamily K member 3 |
|---|
| Ligand | BDBM413516 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Electrophysiological Assay |
|---|
| IC50 | 62.2±7.9 nM |
|---|
| Citation |  Delbeck, M; Hahn, M; Müller, T; Meier, H; Lustig, K; Mosig, J; Toschi, L; Albus, U; Gehring, D; Rosenstein, B Substituted perhydropyrrolo[3,4-c]pyrrole derivatives and the use of same US Patent US10414765 Publication Date 9/17/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Potassium channel subfamily K member 3 |
|---|
| Name: | Potassium channel subfamily K member 3 |
|---|
| Synonyms: | Acid-sensitive potassium channel TASK-1 | Acid-sensitive potassium channel protein TASK-1 | KCNK3 | KCNK3_HUMAN | Potassium channel protein TASK-1 | Potassium channel subfamily K member 3 | Potassium channel subfamily K member 3 (TASK-1) | TASK | TASK1 | TWIK-related acid-sensitive K(+) channel 1 | Two pore K(+) channel KT3.1 | Two pore potassium channel KT3.1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 43534.71 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O14649 |
|---|
| Residue: | 394 |
|---|
| Sequence: | MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYE
ELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPL
TLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSH
YEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLN
LVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVY
AEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRR
CLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV
|
|
|
|---|
| BDBM413516 |
|---|
| n/a |
|---|
| Name | BDBM413516 |
|---|
| Synonyms: | US10414765, Example 25 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H33N5O2 |
|---|
| Mol. Mass. | 495.6153 |
|---|
| SMILES | COc1cccc(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(cc3)C(C)C)CC2C1 |
|---|
| Structure | 
|
|---|
Search and Browse
