Ki Summary

Reaction Details

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Target

Non-receptor tyrosine-protein kinase TYK2

Ligand

BDBM329978

Substrate/Competitor

n/a

Meas. Tech.

Caliper Enzyme Assay

IC50

18.0±n/a nM

Citation

Fensome, A; Gopalsamy, A; Gerstenberger, BS; Efremov, IV; Wan, Z; Pierce, B; Telliez, J; Trujillo, JI; Zhang, L; Xing, L; Saiah, E Aminopyrimidinyl compounds US Patent US10463675 Publication Date 11/5/2019

More Info.:

Get all data from this article, Assay Method

Non-receptor tyrosine-protein kinase TYK2

Name:

Non-receptor tyrosine-protein kinase TYK2

Synonyms:

Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN | Tyrosine-protein kinase TYK2

Type:

Protein

Mol. Mass.:

133666.03

Organism:

Homo sapiens (Human)

Description:

P29597

Residue:

1187

Sequence:

MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI
AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP
AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR
FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP
TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK
AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV
DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP
YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA
GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR
TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS
LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS
ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA
PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ
LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI
RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII
KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYI
HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY
ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC
PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC

BDBM329978

n/a

Name

BDBM329978

Synonyms:

US10463675, Example 61 | US10980815, Ex. No. 61 | US11197867, Example 61 | US9663526, Example 61

Type

Small organic molecule

Emp. Form.

C23H28N8O

Mol. Mass.

432.5214

SMILES

CNC(=O)c1ncc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3[C@H]2C[C@@H](C2)C#N)cc1C |r,wU:23.25,wD:17.24,20.23,25.30,THB:23:22:15.16.21:19.18,(4.67,-6.48,;4.67,-4.94,;3.33,-4.17,;3.33,-2.63,;2,-4.94,;.67,-4.17,;-.67,-4.94,;-.67,-6.48,;-2,-7.25,;-3.33,-6.48,;-4.67,-7.25,;-6,-6.48,;-6,-4.94,;-4.67,-4.17,;-3.33,-4.94,;-4.67,-2.63,;-3.33,-1.86,;-3.33,-.32,;-3.89,-1.29,;-5.43,-1.29,;-6,-.32,;-6,-1.86,;-4.67,.45,;-4.67,1.99,;-5.76,3.08,;-4.67,4.19,;-3.58,3.08,;-4.67,5.73,;-4.67,7.27,;.67,-7.25,;2.05,-6.51,;3.38,-7.28,)|

Structure