Ki Summary

Reaction Details

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Target

Orexin receptor type 2

Ligand

BDBM386070

Substrate/Competitor

n/a

Meas. Tech.

Measurement of Orexin Type 2 Receptor Agonist Activity

EC50

220±n/a nM

Citation

Fujimoto, T; Rikimaru, K; Fukuda, K; Sugimoto, H; Matsumoto, T Substituted piperidine compound and use thereof US Patent US10508083 Publication Date 12/17/2019

More Info.:

Get all data from this article, Assay Method

Orexin receptor type 2

Name:

Orexin receptor type 2

Synonyms:

Type:

Protein

Mol. Mass.:

50710.53

Organism:

Homo sapiens (Human)

Description:

O43614

Residue:

444

Sequence:

MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW

BDBM386070

n/a

Name

BDBM386070

Synonyms:

N-((2R,3S)-2-(((cis-4-(2,5- difluorophenyl)cyclohexyl)oxy)- methyl)piperidin-3- yl)methanesulfonamide | US10287305, Example 10 | US10508083, Example 10 | US11292766, Example 10

Type

Small organic molecule

Emp. Form.

C19H28F2N2O3S

Mol. Mass.

402.499

SMILES

CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1cc(F)ccc1F |r,wU:16.20,13.13,10.11,5.4,(7.34,-.39,;6,.38,;5.23,1.72,;6.77,1.72,;4.67,-.39,;4.67,-1.93,;6,-2.7,;6,-4.24,;4.67,-5.01,;3.33,-4.24,;3.33,-2.7,;2,-1.93,;2,-.39,;.67,.38,;-.67,-.39,;-2,.38,;-2,1.92,;-.67,2.69,;.67,1.92,;-3.33,2.69,;-4.67,1.92,;-6,2.69,;-7.34,1.92,;-6,4.23,;-4.67,5.01,;-3.33,4.23,;-2,5,)|

Structure