Ki Summary

Reaction Details

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Target

Orexin receptor type 2

Ligand

BDBM386079

Substrate/Competitor

n/a

Meas. Tech.

Measurement of Orexin Type 2 Receptor Agonist Activity

EC50

200±n/a nM

Citation

Fujimoto, T; Rikimaru, K; Fukuda, K; Sugimoto, H; Matsumoto, T Substituted piperidine compound and use thereof US Patent US10508083 Publication Date 12/17/2019

More Info.:

Get all data from this article, Assay Method

Orexin receptor type 2

Name:

Orexin receptor type 2

Synonyms:

Type:

Protein

Mol. Mass.:

50710.53

Organism:

Homo sapiens (Human)

Description:

O43614

Residue:

444

Sequence:

MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW

BDBM386079

n/a

Name

BDBM386079

Synonyms:

N-((2R,3S)-2-(((cis-4-(2,3,6- trifluorophenyl)cyclohexyl)oxy)- methyl)piperidin-3- yl)methanesulfonamide | US10287305, Example 21 | US10508083, Example 21 | US11292766, Example 21

Type

Small organic molecule

Emp. Form.

C19H27F3N2O3S

Mol. Mass.

420.489

SMILES

CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1c(F)ccc(F)c1F |r,wU:16.20,13.13,10.11,5.4,(6.67,-1.16,;5.33,-.39,;4.56,.95,;6.1,.95,;4,-1.16,;4,-2.7,;5.33,-3.47,;5.33,-5.01,;4,-5.78,;2.67,-5.01,;2.67,-3.47,;1.33,-2.7,;1.33,-1.16,;,-.39,;-1.33,-1.16,;-2.67,-.39,;-2.67,1.15,;-1.33,1.92,;,1.15,;-4,1.92,;-5.33,1.15,;-5.33,-.38,;-6.67,1.92,;-6.67,3.46,;-5.33,4.24,;-5.33,5.78,;-4,3.46,;-2.67,4.23,)|

Structure