Reaction Details | |||
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Report a problem with these data | |||
Target | Orexin receptor type 2 | ||
Ligand | BDBM386080 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Measurement of Orexin Type 2 Receptor Agonist Activity | ||
EC50 | 5.30±n/a nM | ||
Citation | Fujimoto, T; Rikimaru, K; Fukuda, K; Sugimoto, H; Matsumoto, T Substituted piperidine compound and use thereof US Patent US10508083 Publication Date 12/17/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Orexin receptor type 2 | |||
Name: | Orexin receptor type 2 | ||
Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R | ||
Type: | Protein | ||
Mol. Mass.: | 50710.53 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O43614 | ||
Residue: | 444 | ||
Sequence: |
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BDBM386080 | |||
n/a | |||
Name | BDBM386080 | ||
Synonyms: | N-((2R,3S)-1-acetyl-2-(((cis-4- (2,3,6- trifluorophenyl)cyclohexyl)oxy)- methyl)piperidin-3- yl)methanesulfonamide | US10287305, Example 22 | US10508083, Example 22 | US11292766, Example 22 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H29F3N2O4S | ||
Mol. Mass. | 462.526 | ||
SMILES | CC(=O)N1CCC[C@H](NS(C)(=O)=O)[C@@H]1CO[C@H]1CC[C@H](CC1)c1c(F)ccc(F)c1F |r,wU:19.23,16.16,13.14,7.7,(,-4.23,;1.33,-5,;1.33,-6.54,;2.67,-4.24,;4,-5.01,;5.33,-4.24,;5.33,-2.7,;4,-1.93,;4,-.39,;5.33,.38,;6.67,-.39,;4.56,1.72,;6.1,1.72,;2.67,-2.7,;1.33,-1.93,;1.33,-.39,;,.38,;-1.33,-.39,;-2.67,.38,;-2.67,1.92,;-1.33,2.69,;,1.92,;-4,2.69,;-5.33,1.92,;-5.33,.38,;-6.67,2.69,;-6.67,4.23,;-5.33,5,;-5.33,6.54,;-4,4.23,;-2.67,5,)| | ||
Structure |