Ki Summary

Reaction Details

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Target

Orexin receptor type 2

Ligand

BDBM386081

Substrate/Competitor

n/a

Meas. Tech.

Measurement of Orexin Type 2 Receptor Agonist Activity

EC50

1200±n/a nM

Citation

Fujimoto, T; Rikimaru, K; Fukuda, K; Sugimoto, H; Matsumoto, T Substituted piperidine compound and use thereof US Patent US10508083 Publication Date 12/17/2019

More Info.:

Get all data from this article, Assay Method

Orexin receptor type 2

Name:

Orexin receptor type 2

Synonyms:

Type:

Protein

Mol. Mass.:

50710.53

Organism:

Homo sapiens (Human)

Description:

O43614

Residue:

444

Sequence:

MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW

BDBM386081

n/a

Name

BDBM386081

Synonyms:

N-((2R,3S)-2-(((cis-4-(2- (trifluoromethyl)phenyl)- cyclohexyl)oxy)methyl)piperidin-3- yl)methanesulfonamide | US10287305, Example 23 | US10508083, Example 23 | US11292766, Example 23

Type

Small organic molecule

Emp. Form.

C20H29F3N2O3S

Mol. Mass.

434.516

SMILES

CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1ccccc1C(F)(F)F |r,wU:16.20,13.13,10.11,5.4,(6.67,-1.15,;5.33,-.38,;4.56,.95,;6.1,.95,;4,-1.15,;4,-2.69,;5.33,-3.47,;5.33,-5,;4,-5.78,;2.67,-5,;2.67,-3.47,;1.33,-2.69,;1.33,-1.15,;,-.38,;-1.33,-1.15,;-2.67,-.38,;-2.67,1.15,;-1.33,1.93,;,1.15,;-4,1.93,;-5.33,1.15,;-6.67,1.93,;-6.67,3.47,;-5.33,4.24,;-4,3.47,;-2.67,4.23,;-1.33,3.47,;-2.67,5.78,;-1.33,5,)|

Structure