Ki Summary

Reaction Details

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Target

Orexin receptor type 2

Ligand

BDBM386085

Substrate/Competitor

n/a

Meas. Tech.

Measurement of Orexin Type 2 Receptor Agonist Activity

EC50

310±n/a nM

Citation

Fujimoto, T; Rikimaru, K; Fukuda, K; Sugimoto, H; Matsumoto, T Substituted piperidine compound and use thereof US Patent US10508083 Publication Date 12/17/2019

More Info.:

Get all data from this article, Assay Method

Orexin receptor type 2

Name:

Orexin receptor type 2

Synonyms:

Type:

Protein

Mol. Mass.:

50710.53

Organism:

Homo sapiens (Human)

Description:

O43614

Residue:

444

Sequence:

MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW

BDBM386085

n/a

Name

BDBM386085

Synonyms:

N-((2R,3S)-2-(((cis-4-(2- methoxyphenyl)cyclohexyl)oxy)- methyl)piperidin-3- yl)methanesulfonamide | US10287305, Example 27 | US10508083, Example 27 | US11292766, Example 27

Type

Small organic molecule

Emp. Form.

C20H32N2O4S

Mol. Mass.

396.544

SMILES

COc1ccccc1[C@@H]1CC[C@@H](CC1)OC[C@@H]1NCCC[C@@H]1NS(C)(=O)=O |r,wU:8.8,11.15,16.17,21.24,(-6.67,-.39,;-5.33,.39,;-5.33,1.92,;-6.67,2.69,;-6.67,4.23,;-5.33,5.01,;-4,4.23,;-4,2.69,;-2.67,1.92,;-2.67,.38,;-1.33,-.39,;,.38,;,1.92,;-1.33,2.69,;1.33,-.39,;1.33,-1.93,;2.67,-2.7,;2.67,-4.24,;4,-5.01,;5.33,-4.24,;5.33,-2.7,;4,-1.93,;4,-.39,;5.33,.38,;6.67,-.39,;4.56,1.72,;6.1,1.72,)|

Structure