Ki Summary

Reaction Details

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Target

Orexin receptor type 2

Ligand

BDBM386100

Substrate/Competitor

n/a

Meas. Tech.

Measurement of Orexin Type 2 Receptor Agonist Activity

EC50

940±n/a nM

Citation

Fujimoto, T; Rikimaru, K; Fukuda, K; Sugimoto, H; Matsumoto, T Substituted piperidine compound and use thereof US Patent US10508083 Publication Date 12/17/2019

More Info.:

Get all data from this article, Assay Method

Orexin receptor type 2

Name:

Orexin receptor type 2

Synonyms:

Type:

Protein

Mol. Mass.:

50710.53

Organism:

Homo sapiens (Human)

Description:

O43614

Residue:

444

Sequence:

MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW

BDBM386100

n/a

Name

BDBM386100

Synonyms:

N-(cis-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)-1- (pyrrolidin-1-ylcarbonyl)piperidin- 3-yl)methanesulfonamide | US10287305, Example 39 | US10508083, Example 39 | US11292766, Example 39

Type

Small organic molecule

Emp. Form.

C21H39N3O4S

Mol. Mass.

429.617

SMILES

CC(C)[C@@H]1CC[C@@H](CC1)OC[C@H]1[C@H](CCCN1C(=O)N1CCCC1)NS(C)(=O)=O |r,wU:6.9,11.11,12.26,3.2,(-4.67,5.39,;-4.67,3.85,;-6,3.08,;-3.33,3.08,;-3.33,1.54,;-2,.77,;-.67,1.54,;-.67,3.08,;-2,3.85,;.67,.77,;.67,-.77,;2,-1.54,;3.33,-.77,;4.67,-1.54,;4.67,-3.08,;3.33,-3.85,;2,-3.08,;.67,-3.85,;.67,-5.39,;-.67,-3.08,;-.67,-1.54,;-2.13,-1.06,;-3.04,-2.31,;-2.13,-3.56,;3.33,.77,;4.67,1.54,;6,.77,;3.9,2.87,;5.44,2.87,)|

Structure