Ki Summary

Reaction Details

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Target

Orexin receptor type 2

Ligand

BDBM386112

Substrate/Competitor

n/a

Meas. Tech.

Measurement of Orexin Type 2 Receptor Agonist Activity

EC50

4100±n/a nM

Citation

Fujimoto, T; Rikimaru, K; Fukuda, K; Sugimoto, H; Matsumoto, T Substituted piperidine compound and use thereof US Patent US10508083 Publication Date 12/17/2019

More Info.:

Get all data from this article, Assay Method

Orexin receptor type 2

Name:

Orexin receptor type 2

Synonyms:

Type:

Protein

Mol. Mass.:

50710.53

Organism:

Homo sapiens (Human)

Description:

O43614

Residue:

444

Sequence:

MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW

BDBM386112

n/a

Name

BDBM386112

Synonyms:

N-(cis-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)-1-(3- phenylpropanoyl)piperidin-3- yl)methanesulfonamide | US10287305, Example 54 | US10508083, Example 54 | US11292766, Example 54

Type

Small organic molecule

Emp. Form.

C25H40N2O4S

Mol. Mass.

464.661

SMILES

CC(C)[C@@H]1CC[C@@H](CC1)OC[C@H]1[C@H](CCCN1C(=O)CCc1ccccc1)NS(C)(=O)=O |r,wU:3.2,6.9,11.11,12.29,(-6,4.62,;-4.67,5.39,;-4.67,6.93,;-3.33,4.62,;-3.33,3.08,;-2,2.31,;-.67,3.08,;-.67,4.62,;-2,5.39,;.67,2.31,;.67,.77,;2,,;3.33,.77,;4.67,,;4.67,-1.54,;3.33,-2.31,;2,-1.54,;.67,-2.31,;.67,-3.85,;-.67,-1.54,;-2,-2.31,;-2,-3.85,;-3.33,-4.62,;-3.33,-6.16,;-2,-6.93,;-.67,-6.16,;-.67,-4.62,;3.33,2.31,;4.67,3.08,;6,2.31,;3.9,4.41,;5.44,4.41,)|

Structure