Ki Summary

Reaction Details

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Target

Orexin receptor type 2

Ligand

BDBM386116

Substrate/Competitor

n/a

Meas. Tech.

Measurement of Orexin Type 2 Receptor Agonist Activity

EC50

2300±n/a nM

Citation

Fujimoto, T; Rikimaru, K; Fukuda, K; Sugimoto, H; Matsumoto, T Substituted piperidine compound and use thereof US Patent US10508083 Publication Date 12/17/2019

More Info.:

Get all data from this article, Assay Method

Orexin receptor type 2

Name:

Orexin receptor type 2

Synonyms:

Type:

Protein

Mol. Mass.:

50710.53

Organism:

Homo sapiens (Human)

Description:

O43614

Residue:

444

Sequence:

MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW

BDBM386116

n/a

Name

BDBM386116

Synonyms:

N-(cis-1-(cyclopropylsulfonyl)-2-(((cis- 4-isopropylcyclohexyl)oxy)methyl)- piperidin-3-yl)methanesulfonamide | US10287305, Example 62 | US10508083, Example 62 | US11292766, Example 62

Type

Small organic molecule

Emp. Form.

C19H36N2O5S2

Mol. Mass.

436.63

SMILES

CC(C)[C@@H]1CC[C@@H](CC1)OC[C@H]1[C@H](CCCN1S(=O)(=O)C1CC1)NS(C)(=O)=O |r,wU:3.2,6.9,11.11,12.25,(-6,2.85,;-4.67,3.62,;-4.67,5.16,;-3.33,2.85,;-3.33,1.31,;-2,.54,;-.67,1.31,;-.67,2.85,;-2,3.62,;.67,.54,;.67,-1,;2,-1.77,;3.33,-1,;4.67,-1.77,;4.67,-3.31,;3.33,-4.08,;2,-3.31,;.67,-4.08,;-.42,-5.16,;1.76,-5.16,;-.67,-3.31,;-1.44,-1.97,;-2.21,-3.31,;3.33,.54,;4.67,1.31,;6,.54,;3.9,2.65,;5.44,2.65,)|

Structure