Ki Summary

Reaction Details

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Target

Orexin receptor type 2

Ligand

BDBM386121

Substrate/Competitor

n/a

Meas. Tech.

Measurement of Orexin Type 2 Receptor Agonist Activity

EC50

4300±n/a nM

Citation

Fujimoto, T; Rikimaru, K; Fukuda, K; Sugimoto, H; Matsumoto, T Substituted piperidine compound and use thereof US Patent US10508083 Publication Date 12/17/2019

More Info.:

Get all data from this article, Assay Method

Orexin receptor type 2

Name:

Orexin receptor type 2

Synonyms:

Type:

Protein

Mol. Mass.:

50710.53

Organism:

Homo sapiens (Human)

Description:

O43614

Residue:

444

Sequence:

MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW

BDBM386121

n/a

Name

BDBM386121

Synonyms:

N-(cis-1-acetyl-2-(((1s,4s)-1,1'- bi(cyclohexyl)-4- yloxy)methyl)piperidin-3- yl)methanesulfonamide | US10287305, Example 71 | US10508083, Example 71 | US11292766, Example 71

Type

Small organic molecule

Emp. Form.

C21H38N2O4S

Mol. Mass.

414.602

SMILES

CC(=O)N1CCC[C@H](NS(C)(=O)=O)[C@@H]1CO[C@H]1CC[C@H](CC1)C1CCCCC1 |r,wU:19.23,16.16,13.14,7.7,(,-3.46,;1.33,-4.23,;1.33,-5.77,;2.67,-3.47,;4,-4.24,;5.33,-3.47,;5.33,-1.93,;4,-1.16,;4,.38,;5.33,1.15,;6.67,.38,;4.56,2.49,;6.1,2.49,;2.67,-1.93,;1.33,-1.16,;1.33,.38,;,1.15,;-1.33,.38,;-2.67,1.15,;-2.67,2.69,;-1.33,3.46,;,2.69,;-4,3.46,;-4,5,;-5.33,5.77,;-6.67,5,;-6.67,3.46,;-5.33,2.69,)|

Structure