Reaction Details |
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Target | Orexin receptor type 2 |
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Ligand | BDBM386887 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Measurement of Orexin Type 2 Receptor Agonist Activity |
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EC50 | 490±n/a nM |
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Citation | Fujimoto, T; Rikimaru, K; Fukuda, K; Sugimoto, H; Matsumoto, T Substituted piperidine compound and use thereof US Patent US10508083 Publication Date 12/17/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Orexin receptor type 2 |
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Name: | Orexin receptor type 2 |
Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
Type: | Protein |
Mol. Mass.: | 50710.53 |
Organism: | Homo sapiens (Human) |
Description: | O43614 |
Residue: | 444 |
Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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BDBM386887 |
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n/a |
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Name | BDBM386887 |
Synonyms: | US10287305, Example 338 | US10508083, Example 338 | US11292766, Example 338 | methyl cis-3- ((methylsulfonyl)amino)-2-(((3- phenylcyclopentyl)oxy)methyl)- piperidine-1-carboxylate |
Type | Small organic molecule |
Emp. Form. | C20H30N2O5S |
Mol. Mass. | 410.528 |
SMILES | COC(=O)N1CCC[C@H](NS(C)(=O)=O)[C@@H]1COC1CCC(C1)c1ccccc1 |r| |
Structure |
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