Reaction Details |
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Target | Bromodomain-containing protein 4 [44-164] |
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Ligand | BDBM425419 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Alphascreen Binding Assay |
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IC50 | <1000±n/a nM |
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Citation | Zhang, J; Buell, J; Chan, K; Ibrahim, PN; Lin, J; Pham, P; Shi, S; Spevak, W; Wu, G; Wu, J Heterocyclic compounds and uses thereof US Patent US10519177 Publication Date 12/31/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Bromodomain-containing protein 4 [44-164] |
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Name: | Bromodomain-containing protein 4 [44-164] |
Synonyms: | BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (aa 44-164) | HUNK1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 14412.06 |
Organism: | Homo sapiens (Human) |
Description: | BRD4-BD1 (44-164) |
Residue: | 121 |
Sequence: | NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKT
PMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINE
L
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BDBM425419 |
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n/a |
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Name | BDBM425419 |
Synonyms: | 4-[1-[(4,4-difluorocyclohexyl)methyl]- 6-(3,5-dimethylisoxazol-4- yl)pyrrolo[3,2-b]pyridin-3-yl]benzoic acid | US10519177, Compound P-0324 | US10519177, Compound P-0363 | US10519177, Compound P-0546 |
Type | Small organic molecule |
Emp. Form. | C26H25F2N3O3 |
Mol. Mass. | 465.4918 |
SMILES | Cc1noc(C)c1-c1cnc2c(cn(CC3CCC(F)(F)CC3)c2c1)-c1ccc(cc1)C(O)=O |
Structure |
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