| Reaction Details |
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 | Report a problem with these data |
| Target | Glutaminyl-peptide cyclotransferase |
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| Ligand | BDBM435128 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | QC Inhibition Assay |
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| Ki | 6.00±n/a nM |
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| Citation |  Chen, C; Shih, C; Chen, C; Wang, H; Huang, K Benzimidazole compounds and use thereof for treating Alzheimer's Disease or Huntington's Disease US Patent US10584120 Publication Date 3/10/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutaminyl-peptide cyclotransferase |
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| Name: | Glutaminyl-peptide cyclotransferase |
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| Synonyms: | Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 40877.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16769 |
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| Residue: | 361 |
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| Sequence: | MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGT
SISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSF
SNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLS
LKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHG
MDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYG
GVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLH
L
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| BDBM435128 |
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| n/a |
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| Name | BDBM435128 |
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| Synonyms: | US10584120, Compound 62 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18F2N4O2S |
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| Mol. Mass. | 440.466 |
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| SMILES | COCc1cc(cs1)-c1ccc(C2CNC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F |
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| Structure | 
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