Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetTyrosine-protein kinase JAK1 [866-1154]
LigandBDBM264208
Substrate/Competitorn/a
Meas. Tech.Enzyme Inhibition Assay
IC50 97.0±n/a nM
Citation Astrand, ABGrimster, NPKawatkar, SKettle, JGNilsson, MKRuston, LSu, QVasbinder, MWinter-Holt, JJWoessner, RDChuaqui, CEMcCabe, J Compounds and methods for inhibiting JAK US Patent US10654835 Publication Date 5/19/2020
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase JAK1 [866-1154]
Name:Tyrosine-protein kinase JAK1 [866-1154]
Synonyms:JAK1 | JAK1 (aa 866-1154) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (aa 866-1154)
Type:Protein
Mol. Mass.:33185.74
Organism:Homo sapiens (Human)
Description:P23458[866-1154]
Residue:289
Sequence:
DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKE
IEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAV
QICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPV
FWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLV
NTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM264208
n/a
NameBDBM264208
Synonyms:(2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino] pyrimidin-4-yl}-1H- indol-7-yl)propanamide | US10167276, Example 29 | US10654835, Example 29 | US11247983, Example 29 | US9714236, 29
TypeSmall organic molecule
Emp. Form.C26H33N9O2
Mol. Mass.503.5993
SMILESCOc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: