| Reaction Details |
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 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 4 |
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| Ligand | BDBM249396 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 14.0±n/a nM |
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| Citation |  Chen, L; Guan, D; Bai, H; Gou, J; Zhao, W; Wang, Z; Ling, L; Ma, Y Pyrimidine derivative, method for preparing same and use thereof in medicine US Patent US10654836 Publication Date 5/19/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Fibroblast growth factor receptor 4 |
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| Name: | Fibroblast growth factor receptor 4 |
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| Synonyms: | CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF |
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| Type: | Protein |
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| Mol. Mass.: | 87957.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22455 |
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| Residue: | 802 |
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| Sequence: | MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA
ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS
LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP
TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD
VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP
YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA
AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL
ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ
VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC
TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM
QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA
LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG
LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS
VFSHDPLPLGSSSFPFGSGVQT
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| BDBM249396 |
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| n/a |
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| Name | BDBM249396 |
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| Synonyms: | US10537571, Compound 108 | US10562888, Compound 108 | US10654836, The compound of example 108 of WO2015057938 | US10912774, Compound 108 | US11001572, Example 108 of WO2015057938 | US9434697, 108 | US9730931, Compound 108 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H34Cl2N8O4 |
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| Mol. Mass. | 629.537 |
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| SMILES | CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1 |
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| Structure | 
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