| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 2 |
|---|
| Ligand | BDBM443220 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| IC50 | 777±n/a nM |
|---|
| Citation |  Chen, L; Guan, D; Bai, H; Gou, J; Zhao, W; Wang, Z; Ling, L; Ma, Y Pyrimidine derivative, method for preparing same and use thereof in medicine US Patent US10654836 Publication Date 5/19/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Fibroblast growth factor receptor 2 |
|---|
| Name: | Fibroblast growth factor receptor 2 |
|---|
| Synonyms: | BEK | CD_antigen=CD332 | FGFR-2 | FGFR-2 Tyrosine Kinase | FGFR2 | FGFR2_HUMAN | Fibroblast growth factor receptor 2 (FGFR2) | Fibroblast growth factor receptor 2 precursor | KGFR | KSAM | Keratinocyte growth factor receptor | Keratinocyte growth factor receptor 2 | VEGF-receptor 2 and Fibroblast growth factor receptor 2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 92015.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P21802 |
|---|
| Residue: | 821 |
|---|
| Sequence: | MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK
RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK
LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM
IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF
KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT
TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH
RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS
PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
|
|
|
|---|
| BDBM443220 |
|---|
| n/a |
|---|
| Name | BDBM443220 |
|---|
| Synonyms: | N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-methylureido)pyrimidin-4-yl)amino)-5-(2,7-diazaspiro[3.5]nonan-2-yl)phenyl)acrylamide | US10654836, Example 1 | US11001572, Example 1 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H34Cl2N8O4 |
|---|
| Mol. Mass. | 641.548 |
|---|
| SMILES | COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CC4(C3)CCNCC4)ncn2)c1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
