Reaction Details |
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Target | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
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Ligand | BDBM445090 |
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Substrate/Competitor | n/a |
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Meas. Tech. | UCHL1 Biochemical IC50 Assay |
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IC50 | <100±n/a nM |
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Citation | Kemp, M; Stockley, M; Jones, A Cyanopyrrolidines as dub inhibitors for the treatment of cancer US Patent US10669234 Publication Date 6/2/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
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Name: | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
Synonyms: | Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | UCHL1_HUMAN | Ubiquitin thioesterase L1 |
Type: | PROTEIN |
Mol. Mass.: | 24819.03 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_974327 |
Residue: | 223 |
Sequence: | MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHE
NFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSE
TEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMP
FPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
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BDBM445090 |
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n/a |
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Name | BDBM445090 |
Synonyms: | (2S,4S)-4-fluoro-2-(4-(5-(trifluoromethyl)-1H-pyrazol-4-yl)indoline-1-carbonyl)pyrrolidine-1-carbonitrile | US10669234, Example 29 |
Type | Small organic molecule |
Emp. Form. | C18H15F4N5O |
Mol. Mass. | 393.3382 |
SMILES | F[C@H]1C[C@H](N(C1)C#N)C(=O)N1CCc2c1cccc2-c1cn[nH]c1C(F)(F)F |
Structure |
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