Reaction Details |
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Target | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
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Ligand | BDBM445158 |
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Substrate/Competitor | n/a |
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Meas. Tech. | UCHL1 Biochemical IC50 Assay |
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IC50 | <100±n/a nM |
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Citation | Kemp, M; Stockley, M; Jones, A Cyanopyrrolidines as dub inhibitors for the treatment of cancer US Patent US10669234 Publication Date 6/2/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
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Name: | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
Synonyms: | Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | UCHL1_HUMAN | Ubiquitin thioesterase L1 |
Type: | PROTEIN |
Mol. Mass.: | 24819.03 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_974327 |
Residue: | 223 |
Sequence: | MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHE
NFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSE
TEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMP
FPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
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BDBM445158 |
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n/a |
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Name | BDBM445158 |
Synonyms: | (S)-2-(5-(3-(trifluoro- methyl)-1H-pyrazol-4- yl)isoindoline-2- carbonyl)pyrrolidine-1- carbonitrile | US10669234, Example 115 | US11319287, Example 115 |
Type | Small organic molecule |
Emp. Form. | C18H16F3N5O |
Mol. Mass. | 375.3477 |
SMILES | FC(F)(F)c1n[nH]cc1-c1ccc2CN(Cc2c1)C(=O)[C@@H]1CCCN1C#N |
Structure |
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