| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
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| Ligand | BDBM445166 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | UCHL1 Biochemical IC50 Assay |
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| IC50 | 550±n/a nM |
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| Citation |  Kemp, M; Stockley, M; Jones, A Cyanopyrrolidines as dub inhibitors for the treatment of cancer US Patent US10669234 Publication Date 6/2/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
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| Name: | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
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| Synonyms: | Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | UCHL1_HUMAN | Ubiquitin thioesterase L1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 24819.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_974327 |
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| Residue: | 223 |
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| Sequence: | MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHE
NFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSE
TEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMP
FPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
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| BDBM445166 |
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| n/a |
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| Name | BDBM445166 |
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| Synonyms: | (S)-2-(4-(5H-pyrrolo[2,3- b]pyrazin-7-yl)indoline-1- carbonyl)pyrrolidine-1- carbonitrile | US10669234, Example 123 | US11319287, Example 123 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18N6O |
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| Mol. Mass. | 358.3965 |
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| SMILES | O=C([C@@H]1CCCN1C#N)N1CCc2c1cccc2-c1c[nH]c2nccnc12 |
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| Structure | 
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