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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase BTK | ||
| Ligand | BDBM377362 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Human Recombinant Btk Enzyme Assay | ||
| IC50 | 0.120±n/a nM | ||
| Citation |  Ahmad, S; Batt, DG; Liu, Q; Macor, JE; Tino, JA; Watterson, SH; Nair, SK; Maishal, TK Carbazole derivatives US Patent US10676434 Publication Date 6/9/2020 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase BTK | |||
| Name: | Tyrosine-protein kinase BTK | ||
| Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 76289.95 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q06187 | ||
| Residue: | 659 | ||
| Sequence: |
| ||
| BDBM377362 | |||
| n/a | |||
| Name | BDBM377362 | ||
| Synonyms: | US10266491, Example 30 | US10676434, Example 30 | US11053197, Example 30 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H26FN3O4S | ||
| Mol. Mass. | 495.566 | ||
| SMILES | CN(c1cccc(c1C)-c1c(F)cc(C(N)=O)c2[nH]c3cc(ccc3c12)C(C)(C)O)S(=O)(=O)C=C |(3.75,-5.78,;3.75,-4.23,;2.42,-3.47,;1.08,-4.23,;-.25,-3.47,;-.25,-1.93,;1.08,-1.15,;2.42,-1.93,;3.75,-1.15,;1.08,.38,;2.42,1.15,;3.75,.39,;2.42,2.69,;1.08,3.47,;1.08,5,;2.42,5.78,;-.25,5.78,;-.25,2.69,;-1.71,3.17,;-2.62,1.93,;-4.15,1.76,;-4.78,.36,;-3.87,-.89,;-2.34,-.73,;-1.71,.68,;-.25,1.15,;-6.26,-.04,;-6.66,1.45,;-7.75,.36,;-6.66,-1.53,;5.09,-3.47,;4.32,-2.13,;5.86,-2.13,;6.42,-4.23,;7.75,-3.47,)| | ||
| Structure | 
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