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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase BTK | ||
| Ligand | BDBM377389 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Human Recombinant Btk Enzyme Assay | ||
| IC50 | 0.100±n/a nM | ||
| Citation |  Ahmad, S; Batt, DG; Liu, Q; Macor, JE; Tino, JA; Watterson, SH; Nair, SK; Maishal, TK Carbazole derivatives US Patent US10676434 Publication Date 6/9/2020 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase BTK | |||
| Name: | Tyrosine-protein kinase BTK | ||
| Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 76289.95 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q06187 | ||
| Residue: | 659 | ||
| Sequence: |
| ||
| BDBM377389 | |||
| n/a | |||
| Name | BDBM377389 | ||
| Synonyms: | US10266491, Example 57 | US10266491, Example 58 | US10676434, Example 58 | US11053197, Example 58 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H27ClN4O3 | ||
| Mol. Mass. | 478.971 | ||
| SMILES | CN(C)C(=O)C1CCc2c(C1)[nH]c1c(cc(Cl)c(-c3cccc(NC(=O)C=C)c3C)c21)C(N)=O |(-5.38,-3.39,;-6.46,-2.3,;-7.95,-2.7,;-6.07,-.81,;-7.15,.28,;-4.58,-.41,;-3.67,-1.66,;-2.14,-1.5,;-1.51,-.09,;-2.42,1.15,;-3.95,.99,;-1.51,2.4,;-.05,1.93,;1.28,2.69,;2.62,1.93,;2.62,.38,;3.95,-.38,;1.28,-.38,;1.28,-1.93,;-.05,-2.69,;-.05,-4.23,;1.28,-5,;2.62,-4.23,;3.95,-5,;5.28,-4.23,;5.28,-2.69,;6.62,-5,;7.95,-4.23,;2.62,-2.69,;3.95,-1.93,;-.05,.38,;1.28,4.23,;2.62,5,;-.05,5,)| | ||
| Structure | 
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