Reaction Details | |||
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Target | Tyrosine-protein kinase BTK | ||
Ligand | BDBM377412 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Human Recombinant Btk Enzyme Assay | ||
IC50 | 0.170±n/a nM | ||
Citation | Ahmad, S; Batt, DG; Liu, Q; Macor, JE; Tino, JA; Watterson, SH; Nair, SK; Maishal, TK Carbazole derivatives US Patent US10676434 Publication Date 6/9/2020 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase BTK | |||
Name: | Tyrosine-protein kinase BTK | ||
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 76289.95 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q06187 | ||
Residue: | 659 | ||
Sequence: |
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BDBM377412 | |||
n/a | |||
Name | BDBM377412 | ||
Synonyms: | US10266491, Example 92 | US10676434, Example 92 | US11053197, Example 92 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H18FN3O2 | ||
Mol. Mass. | 399.417 | ||
SMILES | NC(=O)c1cc(F)c(-c2cccc3N(CCc23)C(=O)C=C)c2c3ccccc3[nH]c12 |(1.72,6.54,;.39,5.77,;-.94,6.54,;.39,4.23,;1.72,3.46,;1.72,1.92,;3.06,1.15,;.39,1.15,;.39,-.39,;-.94,-1.16,;-.94,-2.7,;.39,-3.47,;1.72,-2.7,;3.19,-3.17,;4.09,-1.93,;3.19,-.68,;1.72,-1.16,;3.59,-4.66,;2.5,-5.75,;5.07,-5.06,;5.47,-6.54,;-.94,1.92,;-2.41,1.45,;-3.04,.04,;-4.57,-.12,;-5.47,1.13,;-4.85,2.53,;-3.31,2.69,;-2.41,3.94,;-.94,3.46,)| | ||
Structure |