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TargetTyrosine-protein kinase BTK
LigandBDBM377412
Substrate/Competitorn/a
Meas. Tech.Human Recombinant Btk Enzyme Assay
IC50 0.170±n/a nM
Citation Ahmad, SBatt, DGLiu, QMacor, JETino, JAWatterson, SHNair, SKMaishal, TK Carbazole derivatives US Patent US10676434 Publication Date 6/9/2020
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase BTK
Name:Tyrosine-protein kinase BTK
Synonyms:AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:Enzyme
Mol. Mass.:76289.95
Organism:Homo sapiens (Human)
Description:Q06187
Residue:659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM377412
n/a
NameBDBM377412
Synonyms:US10266491, Example 92 | US10676434, Example 92 | US11053197, Example 92
TypeSmall organic molecule
Emp. Form.C24H18FN3O2
Mol. Mass.399.417
SMILESNC(=O)c1cc(F)c(-c2cccc3N(CCc23)C(=O)C=C)c2c3ccccc3[nH]c12 |(1.72,6.54,;.39,5.77,;-.94,6.54,;.39,4.23,;1.72,3.46,;1.72,1.92,;3.06,1.15,;.39,1.15,;.39,-.39,;-.94,-1.16,;-.94,-2.7,;.39,-3.47,;1.72,-2.7,;3.19,-3.17,;4.09,-1.93,;3.19,-.68,;1.72,-1.16,;3.59,-4.66,;2.5,-5.75,;5.07,-5.06,;5.47,-6.54,;-.94,1.92,;-2.41,1.45,;-3.04,.04,;-4.57,-.12,;-5.47,1.13,;-4.85,2.53,;-3.31,2.69,;-2.41,3.94,;-.94,3.46,)|
Structure
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