Reaction Details |
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Target | Tyrosine-protein kinase BTK |
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Ligand | BDBM377470 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Human Recombinant Btk Enzyme Assay |
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IC50 | 0.100±n/a nM |
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Citation | Ahmad, S; Batt, DG; Liu, Q; Macor, JE; Tino, JA; Watterson, SH; Nair, SK; Maishal, TK Carbazole derivatives US Patent US10676434 Publication Date 6/9/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase BTK |
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Name: | Tyrosine-protein kinase BTK |
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) |
Type: | Enzyme |
Mol. Mass.: | 76289.95 |
Organism: | Homo sapiens (Human) |
Description: | Q06187 |
Residue: | 659 |
Sequence: | MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
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BDBM377470 |
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n/a |
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Name | BDBM377470 |
Synonyms: | (S)-4-(3- acrylamidopiperidin-1-yl)-3- fluoro-7-(trifluoromethyl)- 9H-carbazole-1- carboxamide | US10266491, Example 163 | US10676434, Example 163 | US11053197, Example 163 |
Type | Small organic molecule |
Emp. Form. | C22H20F4N4O2 |
Mol. Mass. | 448.4134 |
SMILES | NC(=O)c1cc(F)c(N2CCC[C@@H](C2)NC(=O)C=C)c2c3ccc(cc3[nH]c12)C(F)(F)F |r| |
Structure |
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