Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456559

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

13000±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456559

n/a

Name

BDBM456559

Synonyms:

US10736883, Example 2.0

Type

Small organic molecule

Emp. Form.

C24H23N5O6S

Mol. Mass.

509.534

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)CCN2Cc3ccccc3C2=O)nnc1-c1ccco1 |(-7.67,1.44,;-6.34,.67,;-5.01,1.44,;-5.01,2.98,;-3.67,3.75,;-2.34,2.98,;-2.34,1.44,;-1.01,.67,;.33,1.44,;-3.67,.67,;-3.67,-.87,;-2.43,-1.77,;-.96,-1.3,;.13,-2.39,;-.64,-3.72,;.9,-3.72,;1.46,-1.62,;2.79,-2.39,;4.13,-1.62,;4.29,-.09,;5.8,.23,;6.57,1.57,;8.11,1.57,;8.88,.23,;8.11,-1.1,;6.57,-1.1,;5.53,-2.24,;5.85,-3.75,;-2.9,-3.24,;-4.44,-3.24,;-4.92,-1.77,;-6.38,-1.3,;-6.86,.17,;-8.4,.17,;-8.88,-1.3,;-7.63,-2.2,)|

Structure