Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456561

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

0.770±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456561

n/a

Name

BDBM456561

Synonyms:

US10736883, Example 4.0

Type

Small organic molecule

Emp. Form.

C25H26FN7O6S

Mol. Mass.

571.581

SMILES

COCn1cnc2c(C[C@H](C)S(=O)(=O)Nc3nnc(-c4ccco4)n3-c3c(OC)cccc3OC)ncc(F)c12 |r,wU:9.9,(9.72,4,;8.06,3.64,;6.92,4.91,;5.25,4.55,;4.63,3.15,;3.09,3.31,;2.77,4.82,;1.44,5.59,;.11,4.82,;-1.23,5.59,;-1.23,7.13,;-2.56,4.82,;-3.33,3.48,;-1.79,3.48,;-3.65,5.9,;-5.11,5.43,;-5.59,3.96,;-7.13,3.96,;-7.61,5.43,;-9.07,5.9,;-9.55,7.37,;-11.09,7.37,;-11.56,5.9,;-10.32,5,;-6.36,6.33,;-6.36,7.87,;-5.03,8.64,;-3.69,7.87,;-2.36,8.64,;-5.03,10.18,;-6.36,10.95,;-7.69,10.18,;-7.69,8.64,;-9.03,7.87,;-10.36,8.64,;1.44,7.13,;2.77,7.9,;4.11,7.13,;5.44,7.9,;4.11,5.59,)|

Structure