Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456568

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

0.950±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456568

n/a

Name

BDBM456568

Synonyms:

US10736883, Example 5.0

Type

Small organic molecule

Emp. Form.

C23H22FN7O5S

Mol. Mass.

527.528

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)c3[nH]cnc23)nnc1-c1ccco1 |r,wD:16.17,(-6.73,-3.35,;-5.39,-4.12,;-4.06,-3.35,;-4.06,-1.81,;-2.73,-1.04,;-1.39,-1.81,;-1.39,-3.35,;-.06,-4.12,;1.28,-3.35,;-2.73,-4.12,;-2.73,-5.66,;-1.48,-6.57,;-.02,-6.09,;1.07,-7.18,;1.84,-8.52,;.3,-8.52,;2.41,-6.41,;2.41,-4.87,;3.74,-7.18,;5.07,-6.41,;5.07,-4.87,;6.41,-4.1,;7.74,-4.87,;9.08,-4.1,;7.74,-6.41,;8.89,-7.44,;8.26,-8.85,;6.73,-8.69,;6.41,-7.18,;-1.96,-8.03,;-3.5,-8.03,;-3.97,-6.57,;-5.44,-6.09,;-5.91,-4.63,;-7.45,-4.63,;-7.93,-6.09,;-6.68,-7,)|

Structure