Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456569

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

0.980±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456569

n/a

Name

BDBM456569

Synonyms:

US10736883, Example 6.0

Type

Small organic molecule

Emp. Form.

C24H24FN7O5S

Mol. Mass.

541.555

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)c3n(C)cnc23)nnc1-c1ccco1 |r,wU:16.17,(-8.36,9.28,;-7.02,8.51,;-5.69,9.28,;-5.69,10.82,;-4.36,11.59,;-3.02,10.82,;-3.02,9.28,;-1.69,8.51,;-.36,9.28,;-4.36,8.51,;-4.36,6.97,;-3.11,6.07,;-1.65,6.54,;-.56,5.45,;.21,4.12,;-1.33,4.12,;.78,6.22,;.78,7.76,;2.11,5.45,;3.44,6.22,;3.44,7.76,;4.78,8.53,;6.11,7.76,;7.44,8.53,;6.11,6.22,;7.26,5.19,;8.76,5.51,;6.63,3.79,;5.1,3.95,;4.78,5.45,;-3.59,4.6,;-5.13,4.6,;-5.6,6.07,;-7.07,6.54,;-7.54,8.01,;-9.08,8.01,;-9.56,6.54,;-8.31,5.64,)|

Structure