Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456571

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

28.0±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456571

n/a

Name

BDBM456571

Synonyms:

US10736883, Example 8.0

Type

Small organic molecule

Emp. Form.

C23H22FN7O5S

Mol. Mass.

527.528

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)c3[nH]cnc23)nnc1-c1ccco1 |r,wU:16.17,(-7.89,9.28,;-6.56,8.51,;-5.22,9.28,;-5.22,10.82,;-3.89,11.59,;-2.56,10.82,;-2.56,9.28,;-1.22,8.51,;.11,9.28,;-3.89,8.51,;-3.89,6.97,;-2.64,6.07,;-1.18,6.54,;-.09,5.45,;.68,4.12,;-.86,4.12,;1.24,6.22,;1.24,7.76,;2.58,5.45,;3.91,6.22,;3.91,7.76,;5.24,8.53,;6.58,7.76,;7.91,8.53,;6.58,6.22,;7.72,5.19,;7.1,3.79,;5.56,3.95,;5.24,5.45,;-3.12,4.6,;-4.66,4.6,;-5.14,6.07,;-6.6,6.54,;-7.08,8.01,;-8.62,8.01,;-9.09,6.54,;-7.85,5.64,)|

Structure