Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456572

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

0.091±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456572

n/a

Name

BDBM456572

Synonyms:

US10736883, Example 9.0

Type

Small organic molecule

Emp. Form.

C24H25ClN6O6S

Mol. Mass.

561.01

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(Cl)cc2NC(C)=O)nnc1-c1ccco1 |r,wU:16.17,(.14,-3.48,;-.94,-4.57,;-2.43,-4.17,;-2.83,-2.69,;-4.32,-2.29,;-5.41,-3.38,;-5.01,-4.86,;-6.1,-5.95,;-7.58,-5.55,;-3.52,-5.26,;-3.12,-6.75,;-1.66,-7.23,;-.32,-6.46,;1.01,-7.23,;2.34,-8,;.24,-8.56,;1.78,-5.89,;1.01,-4.56,;3.32,-5.89,;4.09,-4.56,;3.32,-3.22,;4.09,-1.89,;5.63,-1.89,;6.4,-.56,;6.4,-3.22,;5.63,-4.56,;6.4,-5.89,;7.94,-5.89,;8.71,-7.23,;8.71,-4.56,;-1.66,-8.77,;-3.12,-9.24,;-4.03,-8,;-5.51,-7.6,;-6.42,-6.35,;-7.88,-6.83,;-7.88,-8.37,;-6.42,-8.84,)|

Structure