Ki Summary

Reaction Details

Report a problem with these data

Target

Apelin receptor

Ligand

BDBM456576

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

0.190±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456576

n/a

Name

BDBM456576

Synonyms:

US10736883, Example 13.0

Type

Small organic molecule

Emp. Form.

C24H25ClN6O6S

Mol. Mass.

561.01

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(Cl)cc2NC(C)=O)nnc1-c1ccco1 |r,wD:16.17,(-6.81,-2.64,;-5.47,-3.41,;-4.14,-2.64,;-4.14,-1.1,;-2.81,-.33,;-1.47,-1.1,;-1.47,-2.64,;-.14,-3.41,;1.19,-2.64,;-2.81,-3.41,;-2.81,-5.09,;-1.56,-6,;-.23,-5.23,;1.11,-6,;.34,-7.33,;1.88,-7.33,;2.44,-5.23,;2.44,-3.69,;3.77,-6,;5.11,-5.23,;5.11,-3.69,;6.44,-2.92,;7.77,-3.69,;9.11,-2.92,;7.77,-5.23,;6.44,-6,;6.44,-7.54,;7.77,-8.31,;7.77,-9.85,;9.11,-7.54,;-2.04,-7.46,;-3.58,-7.46,;-4.05,-6,;-5.42,-5.41,;-5.9,-3.94,;-7.44,-3.94,;-7.91,-5.41,;-6.67,-6.31,)|

Structure