Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456583

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

0.300±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456583

n/a

Name

BDBM456583

Synonyms:

US10736883, Example 20.0

Type

Small organic molecule

Emp. Form.

C23H21ClN6O5S

Mol. Mass.

528.968

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(Cl)cc2C#N)nnc1-c1ccco1 |r,wU:16.17,(1.08,-3.52,;-.01,-4.6,;-1.5,-4.21,;-1.89,-2.72,;-3.38,-2.32,;-4.47,-3.41,;-4.07,-4.9,;-5.16,-5.99,;-6.65,-5.59,;-2.58,-5.29,;-2.19,-6.78,;-.72,-7.26,;.61,-6.49,;1.95,-7.26,;3.28,-8.03,;1.18,-8.59,;2.72,-5.92,;1.95,-4.59,;4.26,-5.92,;5.03,-4.59,;4.26,-3.26,;5.03,-1.92,;6.57,-1.92,;7.34,-.59,;7.34,-3.26,;6.59,-4.64,;7.36,-5.97,;8.13,-7.31,;-.72,-8.8,;-2.19,-9.27,;-3.09,-8.03,;-4.58,-7.63,;-5.64,-6.54,;-6.95,-6.86,;-6.95,-8.4,;-5.48,-8.88,)|

Structure