Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456584

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

0.310±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456584

n/a

Name

BDBM456584

Synonyms:

US10736883, Example 21.0

Type

Small organic molecule

Emp. Form.

C27H31ClN6O6S

Mol. Mass.

603.09

SMILES

CCN(CC)C(=O)c1cc(Cl)cnc1C[C@H](C)S(=O)(=O)Nc1nnc(-c2ccco2)n1-c1c(OC)cccc1OC |r,wU:15.16,(3.87,-8.47,;4.64,-7.13,;6.18,-7.13,;6.95,-8.47,;6.18,-9.8,;6.95,-5.8,;8.49,-5.8,;6.18,-4.47,;6.95,-3.13,;6.18,-1.8,;6.95,-.47,;4.64,-1.8,;3.87,-3.13,;4.64,-4.47,;3.87,-5.8,;2.33,-5.8,;1.56,-4.47,;1.56,-7.13,;2.89,-7.9,;.79,-8.47,;.22,-6.36,;-1.11,-7.13,;-1.11,-8.67,;-2.57,-9.15,;-3.48,-7.9,;-4.97,-7.51,;-5.87,-6.26,;-7.34,-6.74,;-7.34,-8.28,;-5.87,-8.75,;-2.57,-6.66,;-2.97,-5.17,;-1.88,-4.08,;-.4,-4.48,;.69,-3.39,;-2.28,-2.6,;-3.77,-2.2,;-4.86,-3.29,;-4.46,-4.77,;-5.55,-5.86,;-7.04,-5.46,)|

Structure