Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456585

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

0.310±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456585

n/a

Name

BDBM456585

Synonyms:

US10736883, Example 22.0

Type

Small organic molecule

Emp. Form.

C21H21BrN6O5S

Mol. Mass.

549.398

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(Br)cn2)nnc1-c1ccco1 |r,wU:16.17,(-7.77,5.88,;-6.43,5.11,;-5.1,5.88,;-5.1,7.42,;-3.76,8.19,;-2.43,7.42,;-2.43,5.88,;-1.1,5.11,;.24,5.88,;-3.76,5.11,;-3.76,3.43,;-2.52,2.52,;-1.03,2.92,;.06,1.83,;-.71,.5,;.83,.5,;1.39,2.6,;1.39,4.14,;2.73,1.83,;4.06,2.6,;5.39,1.83,;6.73,2.6,;6.73,4.14,;8.06,4.91,;5.39,4.91,;4.06,4.14,;-2.99,1.06,;-4.53,1.06,;-5.01,2.52,;-6.38,3.11,;-6.86,4.57,;-8.4,4.57,;-8.87,3.11,;-7.63,2.2,)|

Structure