Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456588

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

0.370±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456588

n/a

Name

BDBM456588

Synonyms:

US10736883, Example 25.0

Type

Small organic molecule

Emp. Form.

C22H22FN5O5S

Mol. Mass.

487.504

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ccc(F)cn2)nnc1-c1ccco1 |r,wU:16.17,(-6.08,-5.5,;-4.59,-5.9,;-3.51,-4.81,;-3.9,-3.32,;-2.82,-2.23,;-1.33,-2.63,;-.93,-4.12,;.56,-4.52,;1.65,-3.43,;-2.02,-5.21,;-1.51,-7.2,;-.18,-7.97,;1.16,-7.2,;2.49,-7.97,;1.72,-9.3,;3.82,-8.74,;3.26,-6.64,;2.49,-5.3,;4.8,-6.64,;5.57,-5.3,;7.11,-5.3,;7.88,-3.97,;7.11,-2.63,;7.88,-1.3,;5.57,-2.63,;4.8,-3.97,;-.5,-9.48,;-2.03,-9.64,;-2.66,-8.23,;-4.14,-7.83,;-4.84,-6.46,;-6.36,-6.7,;-6.6,-8.22,;-5.23,-8.92,)|

Structure