Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456591

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

0.480±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456591

n/a

Name

BDBM456591

Synonyms:

US10736883, Example 28.0

Type

Small organic molecule

Emp. Form.

C24H25FN6O6S

Mol. Mass.

544.555

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cc2NC(C)=O)nnc1-c1ccco1 |r,wU:16.17,(-7.43,-6.02,;-5.95,-6.42,;-4.86,-5.33,;-5.26,-3.84,;-4.17,-2.75,;-2.68,-3.15,;-2.28,-4.64,;-.79,-5.04,;.29,-3.95,;-3.37,-5.73,;-2.86,-7.72,;-1.53,-8.49,;-.2,-7.72,;1.14,-8.49,;.37,-9.83,;2.47,-9.26,;1.91,-7.16,;1.14,-5.82,;3.45,-7.16,;4.22,-5.82,;3.45,-4.49,;4.22,-3.16,;5.76,-3.16,;6.53,-1.82,;6.53,-4.49,;5.76,-5.82,;6.53,-7.16,;8.07,-7.16,;8.84,-8.49,;8.84,-5.82,;-1.85,-10,;-3.38,-10.16,;-4.01,-8.75,;-5.5,-8.35,;-6.19,-6.98,;-7.72,-7.22,;-7.96,-8.74,;-6.58,-9.44,)|

Structure