Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456592

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

0.820±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456592

n/a

Name

BDBM456592

Synonyms:

US10736883, Example 29.0

Type

Small organic molecule

Emp. Form.

C23H21FN6O5S

Mol. Mass.

512.513

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cc2C#N)nnc1-c1ccco1 |r,wU:16.17,(-6.47,-5.5,;-4.99,-5.9,;-3.9,-4.81,;-4.3,-3.32,;-3.21,-2.23,;-1.72,-2.63,;-1.32,-4.12,;.17,-4.52,;1.26,-3.43,;-2.41,-5.21,;-1.9,-7.2,;-.57,-7.97,;.76,-7.2,;2.1,-7.97,;1.33,-9.3,;3.43,-8.74,;2.87,-6.64,;2.1,-5.3,;4.41,-6.64,;5.18,-5.3,;4.41,-3.97,;5.18,-2.63,;6.72,-2.63,;7.49,-1.3,;7.49,-3.97,;6.75,-5.35,;7.52,-6.68,;8.29,-8.02,;-.89,-9.48,;-2.42,-9.64,;-3.05,-8.23,;-4.53,-7.83,;-5.23,-6.46,;-6.75,-6.7,;-7,-8.22,;-5.62,-8.92,)|

Structure