Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456593

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

1.20±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456593

n/a

Name

BDBM456593

Synonyms:

US10736883, Example 30.0

Type

Small organic molecule

Emp. Form.

C23H22N6O5S

Mol. Mass.

494.523

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ccc(cn2)C#N)nnc1-c1ccco1 |r,wU:16.17,(-6.47,-6.16,;-4.99,-6.56,;-3.9,-5.47,;-4.3,-3.99,;-3.21,-2.9,;-1.72,-3.3,;-1.32,-4.78,;.17,-5.18,;1.26,-4.09,;-2.41,-5.87,;-1.9,-7.87,;-.57,-8.64,;.76,-7.87,;2.1,-8.64,;1.33,-9.97,;3.43,-9.41,;2.87,-7.3,;2.1,-5.97,;4.41,-7.3,;5.18,-5.97,;6.72,-5.97,;7.49,-4.63,;6.75,-3.25,;5.18,-3.3,;4.41,-4.63,;7.52,-1.92,;8.29,-.59,;-.89,-10.14,;-2.42,-10.3,;-3.05,-8.9,;-4.53,-8.5,;-5.23,-7.13,;-6.75,-7.37,;-7,-8.89,;-5.62,-9.59,)|

Structure