Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456594

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

1.90±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456594

n/a

Name

BDBM456594

Synonyms:

US10736883, Example 31.0

Type

Small organic molecule

Emp. Form.

C23H26N6O5S

Mol. Mass.

498.555

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ccc(C)nn2)nnc1-c1ccc(C)o1 |r,wU:16.17,(-5.44,-5.53,;-3.95,-5.93,;-2.86,-4.84,;-3.26,-3.35,;-2.17,-2.27,;-.69,-2.66,;-.29,-4.15,;1.2,-4.55,;2.29,-3.46,;-1.38,-5.24,;-.87,-7.23,;.46,-8,;1.8,-7.23,;3.13,-8,;2.36,-9.34,;4.46,-8.77,;3.9,-6.67,;3.13,-5.34,;5.44,-6.67,;6.21,-5.34,;7.75,-5.34,;8.52,-4,;7.75,-2.67,;8.52,-1.34,;6.21,-2.67,;5.44,-4,;.14,-9.51,;-1.39,-9.67,;-2.01,-8.26,;-3.5,-7.87,;-4.2,-6.49,;-5.72,-6.73,;-5.96,-8.26,;-7.3,-9.03,;-4.59,-8.95,)|

Structure