Ki Summary

Reaction Details

Report a problem with these data

Target

Apelin receptor

Ligand

BDBM456595

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

2.30±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456595

n/a

Name

BDBM456595

Synonyms:

US10736883, Example 32.0

Type

Small organic molecule

Emp. Form.

C22H24N6O5S

Mol. Mass.

484.528

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2cnc(C)cn2)nnc1-c1ccco1 |r,wU:16.17,(-6.08,-5.53,;-4.59,-5.93,;-3.5,-4.84,;-3.9,-3.35,;-2.81,-2.27,;-1.33,-2.66,;-.93,-4.15,;.56,-4.55,;1.65,-3.46,;-2.02,-5.24,;-1.51,-7.23,;-.18,-8,;1.16,-7.23,;2.49,-8,;1.72,-9.34,;3.83,-8.77,;3.26,-6.67,;2.49,-5.34,;4.8,-6.67,;5.57,-5.34,;7.11,-5.34,;7.88,-4,;7.11,-2.67,;7.88,-1.34,;5.57,-2.67,;4.8,-4,;-.5,-9.51,;-2.03,-9.67,;-2.65,-8.26,;-4.14,-7.87,;-4.84,-6.49,;-6.36,-6.73,;-6.6,-8.26,;-5.23,-8.95,)|

Structure