Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456596

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

2.40±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456596

n/a

Name

BDBM456596

Synonyms:

US10736883, Example 33.0

Type

Small organic molecule

Emp. Form.

C24H24N6O5S

Mol. Mass.

508.55

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ccc(cn2)C#N)nnc1-c1ccc(C)o1 |r,wU:16.17,(-5.81,-6.16,;-4.32,-6.56,;-3.23,-5.47,;-3.63,-3.99,;-2.54,-2.9,;-1.05,-3.3,;-.65,-4.78,;.83,-5.18,;1.92,-4.09,;-1.74,-5.87,;-1.24,-7.87,;.1,-8.64,;1.43,-7.87,;2.77,-8.64,;2,-9.97,;4.1,-9.41,;3.54,-7.3,;2.77,-5.97,;5.08,-7.3,;5.85,-5.97,;7.39,-5.97,;8.16,-4.63,;7.41,-3.25,;5.85,-3.3,;5.08,-4.63,;8.18,-1.92,;8.95,-.59,;-.22,-10.14,;-1.75,-10.3,;-2.38,-8.9,;-3.87,-8.5,;-4.57,-7.13,;-6.09,-7.37,;-6.33,-8.89,;-7.66,-9.66,;-4.96,-9.59,)|

Structure