Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456597

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

3.20±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456597

n/a

Name

BDBM456597

Synonyms:

US10736883, Example 34.0

Type

Small organic molecule

Emp. Form.

C20H19FN6O5S

Mol. Mass.

474.465

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)CCc2ncc(F)cn2)nnc1-c1ccco1 |(-6.72,-.03,;-5.23,-.43,;-4.14,.66,;-4.54,2.15,;-3.45,3.24,;-1.97,2.84,;-1.57,1.35,;-.08,.95,;1.01,2.04,;-2.66,.26,;-2.15,-1.73,;-.82,-2.5,;.52,-1.73,;1.85,-2.5,;1.08,-3.83,;3.19,-3.27,;2.62,-1.17,;4.16,-1.17,;4.93,.17,;6.47,.17,;7.24,1.5,;6.47,2.83,;7.24,4.17,;4.93,2.83,;4.16,1.5,;-1.14,-4.01,;-2.67,-4.17,;-3.29,-2.76,;-4.78,-2.36,;-5.48,-.99,;-7,-1.23,;-7.24,-2.75,;-5.87,-3.45,)|

Structure