Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456598

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

3.50±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456598

n/a

Name

BDBM456598

Synonyms:

US10736883, Example 35.0

Type

Small organic molecule

Emp. Form.

C22H20N6O5S

Mol. Mass.

480.496

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)CCc2ccc(cn2)C#N)nnc1-c1ccco1 |(-7.4,-1.04,;-5.92,-1.44,;-4.83,-.35,;-5.23,1.13,;-4.14,2.22,;-2.65,1.82,;-2.25,.34,;-.76,-.06,;.33,1.03,;-3.34,-.75,;-2.7,-2.48,;-1.26,-3.03,;.07,-2.26,;1.4,-3.03,;2.74,-3.8,;.63,-4.37,;2.17,-1.7,;3.71,-1.7,;4.48,-.37,;6.02,-.37,;6.79,.97,;6.05,2.35,;4.48,2.3,;3.71,.97,;6.82,3.68,;7.59,5.02,;-1.34,-4.57,;-2.83,-4.97,;-3.67,-3.68,;-5.16,-3.28,;-6,-1.99,;-7.48,-2.39,;-7.56,-3.92,;-6.13,-4.48,)|

Structure