Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456599

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

3.50±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456599

n/a

Name

BDBM456599

Synonyms:

US10736883, Example 36.0

Type

Small organic molecule

Emp. Form.

C21H21BrN6O5S

Mol. Mass.

549.398

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(Br)cn2)nnc1-c1ccco1 |r,wD:16.17,(-7.14,6.11,;-5.66,5.71,;-4.57,6.8,;-4.96,8.29,;-3.88,9.38,;-2.39,8.98,;-1.99,7.49,;-.5,7.09,;.59,8.18,;-3.08,6.4,;-2.5,4.55,;-1.09,3.93,;.24,4.7,;1.57,3.93,;.49,2.84,;2.91,3.16,;2.34,5.26,;1.57,6.59,;3.88,5.26,;4.65,6.59,;6.19,6.59,;6.96,7.93,;6.19,9.26,;6.96,10.59,;4.65,9.26,;3.88,7.93,;-1.25,2.39,;-2.76,2.07,;-3.53,3.41,;-5.02,3.81,;-5.57,5.24,;-7.11,5.16,;-7.51,3.68,;-6.21,2.84,)|

Structure