Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456600

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

3.60±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456600

n/a

Name

BDBM456600

Synonyms:

US10736883, Example 37.0

Type

Small organic molecule

Emp. Form.

C21H21ClN6O5S

Mol. Mass.

504.947

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(Cl)cn2)nnc1-c1ccco1 |r,wU:16.17,(-6.29,-7.06,;-4.8,-7.45,;-3.71,-6.36,;-4.11,-4.88,;-3.02,-3.79,;-1.53,-4.19,;-1.14,-5.67,;.35,-6.07,;1.44,-4.98,;-2.23,-6.76,;-1.59,-8.49,;-.15,-9.04,;1.19,-8.27,;2.52,-9.04,;3.85,-9.81,;1.75,-10.38,;3.29,-7.71,;2.52,-6.38,;4.83,-7.71,;5.6,-6.38,;7.14,-6.38,;7.91,-5.04,;7.14,-3.71,;7.91,-2.37,;5.6,-3.71,;4.83,-5.04,;-.23,-10.58,;-1.72,-10.98,;-2.56,-9.69,;-4.04,-9.29,;-4.88,-8,;-6.37,-8.4,;-6.45,-9.93,;-5.01,-10.49,)|

Structure