Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456601

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

3.80±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456601

n/a

Name

BDBM456601

Synonyms:

US10736883, Example 38.0

Type

Small organic molecule

Emp. Form.

C23H26N6O5S

Mol. Mass.

498.555

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2cnc(C)cn2)nnc1-c1ccc(C)o1 |r,wD:16.17,(-6.21,-4.58,;-4.87,-5.35,;-3.54,-4.58,;-3.54,-3.04,;-2.2,-2.27,;-.87,-3.04,;-.87,-4.58,;.46,-5.35,;1.8,-4.58,;-2.2,-5.35,;-2.2,-7.37,;-.96,-8.27,;.53,-7.87,;1.62,-8.96,;.85,-10.3,;2.39,-10.3,;2.95,-8.19,;2.95,-6.65,;4.29,-8.96,;5.62,-8.19,;6.95,-8.96,;8.29,-8.19,;8.29,-6.65,;9.62,-5.88,;6.95,-5.88,;5.62,-6.65,;-1.43,-9.74,;-2.97,-9.74,;-3.45,-8.27,;-4.78,-7.5,;-5.26,-6.04,;-6.8,-6.04,;-7.28,-7.5,;-8.61,-8.27,;-6.03,-8.41,)|

Structure