Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456605

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

12.0±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456605

n/a

Name

BDBM456605

Synonyms:

US10736883, Example 42.0

Type

Small organic molecule

Emp. Form.

C22H24N6O5S

Mol. Mass.

484.528

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ccc(C)nn2)nnc1-c1ccco1 |r,wU:16.17,(-6.18,-7.22,;-4.69,-7.62,;-3.6,-6.53,;-4,-5.05,;-2.91,-3.96,;-1.43,-4.36,;-1.03,-5.84,;.46,-6.24,;1.55,-5.15,;-2.12,-6.93,;-1.48,-8.66,;-.04,-9.21,;1.29,-8.44,;2.63,-9.21,;3.96,-9.98,;1.86,-10.55,;3.4,-7.88,;2.63,-6.54,;4.94,-7.88,;5.71,-6.54,;7.25,-6.54,;8.02,-5.21,;7.25,-3.88,;8.02,-2.54,;5.71,-3.88,;4.94,-5.21,;-.12,-10.75,;-1.61,-11.15,;-2.45,-9.86,;-3.93,-9.46,;-4.77,-8.17,;-6.26,-8.57,;-6.34,-10.1,;-4.9,-10.65,)|

Structure