Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456608

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

72.0±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456608

n/a

Name

BDBM456608

Synonyms:

US10736883, Example 45.0

Type

Small organic molecule

Emp. Form.

C21H22N6O5S

Mol. Mass.

470.502

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2cncnc2)nnc1-c1ccco1 |r,wD:16.17,(-6.97,-5.22,;-5.48,-5.62,;-4.39,-4.53,;-4.79,-3.05,;-3.7,-1.96,;-2.21,-2.35,;-1.81,-3.84,;-.33,-4.24,;.76,-3.15,;-2.9,-4.93,;-2.26,-6.66,;-.83,-7.21,;.51,-6.44,;1.84,-7.21,;1.07,-8.55,;2.61,-5.88,;3.17,-7.98,;3.17,-9.52,;4.51,-7.21,;5.84,-7.98,;5.84,-9.52,;7.18,-10.29,;8.51,-9.52,;8.51,-7.98,;7.18,-7.21,;-.91,-8.75,;-2.39,-9.15,;-3.23,-7.86,;-4.72,-7.46,;-5.56,-6.17,;-7.05,-6.56,;-7.13,-8.1,;-5.69,-8.65,)|

Structure