Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456609

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

300±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456609

n/a

Name

BDBM456609

Synonyms:

US10736883, Example 46.0

Type

Small organic molecule

Emp. Form.

C21H22N6O5S

Mol. Mass.

470.502

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ccncn2)nnc1-c1ccco1 |r,wU:16.17,(-6.31,-5.56,;-4.82,-5.96,;-3.73,-4.87,;-4.13,-3.38,;-3.04,-2.29,;-1.55,-2.69,;-1.16,-4.18,;.33,-4.58,;1.42,-3.49,;-2.24,-5.27,;-1.61,-6.99,;-.17,-7.55,;1.17,-6.78,;2.5,-7.55,;3.83,-8.32,;1.73,-8.88,;3.27,-6.21,;2.5,-4.88,;4.81,-6.21,;5.58,-4.88,;7.12,-4.88,;7.89,-3.55,;7.12,-2.21,;5.58,-2.21,;4.81,-3.55,;-.25,-9.08,;-1.74,-9.48,;-2.57,-8.19,;-4.06,-7.79,;-4.9,-6.5,;-6.39,-6.9,;-6.47,-8.44,;-5.03,-8.99,)|

Structure