Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456612

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

3.40±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456612

n/a

Name

BDBM456612

Synonyms:

US10736883, Example 53.0

Type

Small organic molecule

Emp. Form.

C25H30N6O5S

Mol. Mass.

526.608

SMILES

CCc1cnc(nc1)[C@@H](C)[C@H](C)S(=O)(=O)Nc1nnc(-c2ccc(C)o2)n1-c1c(OC)cccc1OC |r,wU:8.9,10.11,(10.12,-.96,;10.12,-2.5,;8.79,-3.27,;8.79,-4.81,;7.45,-5.58,;6.12,-4.81,;6.12,-3.27,;7.45,-2.5,;4.78,-5.58,;4.78,-7.12,;3.45,-4.81,;3.45,-3.27,;2.12,-5.58,;.78,-6.35,;2.89,-6.92,;1.35,-4.25,;-.19,-4.25,;-1.1,-5.49,;-2.56,-5.02,;-2.56,-3.48,;-3.81,-2.57,;-3.81,-1.03,;-5.27,-.56,;-6.18,-1.8,;-7.72,-1.8,;-5.27,-3.05,;-1.1,-3,;-.62,-1.54,;-1.65,-.39,;-3.16,-.71,;-4.19,.43,;-1.18,1.07,;.33,1.39,;1.36,.25,;.88,-1.22,;1.91,-2.36,;3.42,-2.03,)|

Structure